Rejuran Healer is one of Korea's best-known skin boosters. This guide explains what is in it, what it can do for your skin, what recovery looks like and how to plan sessions during a trip to Seoul.
Rejuran Healer is a polynucleotide (PN) skin booster made by Pharma Research in Korea, with PN derived from salmon DNA. Injected into the skin, it supports repair, thickness and elasticity, helping tired, thin, sensitive or textured skin look healthier. Expect small bumps for one to three days, and plan three sessions two to four weeks apart for best results. At Dernia Clinic Myeongdong in Seoul, Rejuran Healer starts from ₩259,000 for 2cc (full face), with 3cc at ₩359,000 and 4cc including the neck at ₩469,000 (KRW, excluding 10% VAT).
Prices are in Korean won, exclude 10% VAT and are confirmed by a doctor at consultation.
What is Rejuran Healer?
Rejuran Healer is an injectable skin booster developed by Pharma Research, a Korean pharmaceutical company. It is based on polynucleotides (PN), long chains of DNA fragments that are purified from salmon. Rejuran is widely used in Korean dermatology clinics to improve overall skin quality rather than to add volume or change shape.
Unlike filler, Rejuran does not fill lines directly. It is placed in tiny amounts across the skin to support the skin's own repair environment. Read more on our Rejuran Healer treatment page.
What are the ingredients in Rejuran Healer?
The active ingredient is polynucleotide (PN), sometimes described as a salmon DNA booster. In general terms:
- Source: PN is extracted and highly purified from salmon DNA.
- Function: polynucleotides are thought to support the repair environment of skin cells, helping fibroblasts — the cells that produce collagen — work more effectively.
- Hydration: PN binds water, which contributes to improved hydration and a healthier look.
- No cross-linking agents: it is not a filler, so it does not create volume or a defined shape.
Because it is derived from fish, people with a fish allergy should discuss this with the doctor before treatment. More detail is in is Rejuran made from salmon?
Benefits of Rejuran Healer
1. Better skin texture and thickness
Many people notice skin feels smoother, more resilient and slightly thicker after a series of treatments.
2. Calmer, less reactive skin
Rejuran is popular for sensitive or easily irritated skin and is often used to support skin after lasers or other procedures.
3. Softer fine lines and pores
As skin quality improves, fine lines and the appearance of pores may soften.
4. Natural-looking result
Because it does not add volume, results look like healthier skin rather than a visible change in shape. That makes it a popular choice for people who want to look well rested without anyone noticing a treatment.
For the eye area, a finer formula called Rejuran Eye (Rejuran I) is used instead. See Rejuran Eye.
Rejuran Healer vs other Korean skin boosters
Seoul clinics offer many skin boosters, and they are not interchangeable. Choosing the right one depends on what your skin needs most.
- Rejuran Healer vs hyaluronic acid boosters: HA boosters mainly draw in water for quick hydration and glow, with results lasting about one to three months. Rejuran focuses more on repair and skin thickness, and its effect builds over a series.
- Rejuran Healer vs Profhilo: Profhilo is a high-concentration HA that spreads through the skin to improve laxity and hydration with only five injection points per side. Rejuran uses many small injections and targets skin quality and sensitivity.
- Rejuran Healer vs Juvelook: Juvelook uses PDLLA particles to stimulate collagen for texture and shallow scars. Rejuran has no particles and is often chosen for sensitive or thin skin.
- Rejuran Healer vs exosome therapy: exosomes are applied after microneedling or laser to support recovery. Research is promising but still developing, and the two are sometimes used together.
- Rejuran Healer vs Chanel injection: NCTF 135HA combines non-crosslinked HA with vitamins and amino acids for glow, while Rejuran targets repair.
Many people combine Rejuran with an HA booster or an energy-based treatment. Read skin boosters explained for a fuller comparison, and see Rejuran Healer vs Juvelook for a direct breakdown.
Who is a good candidate for Rejuran Healer?
Usually a good fit
- Thin, dull or tired-looking skin
- Sensitive or easily irritated skin
- Fine lines, enlarged pores or rough texture
- Skin recovering from lasers or sun damage
- People who want natural improvement without volume
Talk to the doctor first
- Fish or salmon allergy
- Pregnancy or breastfeeding
- Active skin infection or inflammation in the area
- Bleeding disorders or blood thinners
- Expectation of an immediate, dramatic change
What happens on Rejuran treatment day
- English consultation. A licensed doctor examines your skin, confirms Rejuran suits you and agrees the volume and price.
- Numbing. Numbing cream is applied for about 30 minutes, because Rejuran injections can sting more than other boosters.
- Injection. The doctor places many tiny amounts across the face, either by hand or with an injector device.
- Soothing. A calming mask or cool pack settles the skin before you leave.
Many visitors ask whether Rejuran hurts. It can be one of the more uncomfortable boosters, but numbing helps significantly. See does Rejuran hurt?
Rejuran Healer recovery and aftercare
| When | What to expect |
|---|---|
| Day 0 | Small raised bumps at injection points, redness and occasional pinpoint bleeding |
| Days 1–3 | Bumps flatten; minor bruising possible in some areas |
| Weeks 2–4 | Skin looks smoother and more hydrated |
| After 3 sessions | Fuller improvement in texture, thickness and resilience |
| About every 6 months | Maintenance session to keep results |
- First day: avoid makeup for several hours if possible, and do not rub or massage the area.
- First two days: skip saunas, jjimjilbang, hot baths, intense exercise and alcohol, which can increase swelling.
- Every day: use gentle skincare and broad-spectrum sunscreen.
Read when will I see Rejuran results? for more on timing.
Is Rejuran Healer safe? Side effects
Rejuran Healer is widely used in Korea and generally well tolerated. Common, temporary effects include small bumps, redness, mild swelling, tenderness and occasional bruising, which usually settle within one to three days. Less common effects include longer-lasting bumps or small lumps. Rare risks, as with any injection, include infection and allergic reaction, particularly in people with fish allergy. Choosing a doctor-led clinic using genuine product helps reduce risk.
Flying home? Most people can fly the day after Rejuran. Small bumps may still be visible but do not affect travel. See our guide to flying after injectables and boosters.
How much does Rejuran Healer cost in Seoul (2026)?
| Plan | Typical coverage | Price (KRW) |
|---|---|---|
| 2cc | Full face, standard coverage | ₩259,000 |
| 3cc | Full face with extra on cheeks, pores or scars | ₩359,000 |
| 4cc | Full face and neck | ₩469,000 |
Prices exclude 10% VAT. The tourist VAT refund on cosmetic procedures ended on January 1, 2026 — see VAT refund changes. Full details on the Rejuran Healer price page.
Dernia does not currently offer Rejuran S (the formula designed for scars). For acne scars, ask at consultation about options such as Potenza RF microneedling or CO2 fractional laser.
Planning Rejuran around your Seoul trip
- Book ahead. Send your dates through our consultation form; if you stay two to four weeks, you may fit two sessions into one trip.
- Avoid your arrival day. Rest first and book treatment from day two.
- Allow time for bumps. Schedule Rejuran a day or two before important photos or events.
- Getting here. Dernia is in Myeongdong, near Myeongdong Station (Line 4) and Euljiro 1-ga Station (Line 2).
Frequently asked questions
What is Rejuran Healer made of?
Its active ingredient is polynucleotide (PN), purified from salmon DNA. It is a skin booster, not a filler.
Does Rejuran Healer hurt?
It can sting more than some other boosters, but numbing cream makes it manageable for most people.
How many Rejuran sessions do I need?
Most people plan three sessions, two to four weeks apart, followed by maintenance about every six months.
How long do Rejuran bumps last?
Small bumps usually flatten within one to three days.
Can I get Rejuran if I have a fish allergy?
Rejuran is derived from salmon, so tell the doctor about any fish allergy. It may not be suitable for you.
Does Dernia offer Rejuran S for scars?
Not currently. The doctor can suggest alternatives for acne scars, such as Potenza RF microneedling or CO2 fractional laser.
Can I fly after Rejuran?
Yes. Most people fly the next day; small bumps may still be visible but do not affect travel.
Interested in Rejuran Healer in Seoul?
Tell us your skin concerns and travel dates. A doctor examines your skin in person, explains options in English and confirms your plan and price before treatment.
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This article is for general information and does not replace a medical consultation. Results vary between individuals, and suitability, treatment plan and final price are confirmed by a licensed doctor after an in-person examination. Dernia Clinic Myeongdong does not publish patient testimonials or before-and-after claims.