Rejuran Healer vs Profhilo at a glance

These are two of the most requested skin boosters in Seoul, and they are often confused. Rejuran Healer is a polynucleotide repair booster that strengthens and calms the skin. Profhilo is a hyaluronic acid bio-remodeler that hydrates deeply and improves firmness. Each does something the other does not.

Feature	Rejuran Healer	Profhilo
Technology	Polynucleotides (PN) from salmon DNA (Pharma Research)	High-concentration hybrid hyaluronic acid (IBSA)
How it works / target depth	Many small injections across the dermis support repair and elasticity	Ten injection points; the gel spreads in the superficial layers to hydrate and firm
Best for	Sensitive or red skin, pores, fine lines, shallow scars, thin skin	Dehydrated, crepey or mildly lax skin on the face, neck and hands
Comfort	Known to sting; numbing cream used	Ten quick injections; brief sting as the gel spreads
Downtime	Small bumps for 1–3 days	Small bumps for about 24 hours
Sessions	Usually 3, about 3–4 weeks apart	Usually 2, about 4 weeks apart
Results appear	Calmer, healthier skin within weeks; builds with each session	Hydration within days; firmness builds after the second session
Results last	Builds over 3 sessions; maintenance every 6 months	About 6 months after 2 sessions
Price from at Dernia	₩259,000 (2cc, full face)	₩390,000 (2ml, 1 session)

How Rejuran Healer works

Rejuran Healer, made by Pharma Research in Korea, contains purified polynucleotides from salmon DNA. Injected in small amounts across the face, PN supports the skin's repair processes, helps calm inflammation and improves hydration and elasticity. Over a series, skin tends to look thicker, more even and less reactive, with softer fine lines and refined pores. Because it is delivered through many injections, it can sting, so numbing cream is applied first.

How Profhilo works

Profhilo, from IBSA in Italy, packs a high concentration of hyaluronic acid into a heat-stabilized hybrid gel without chemical cross-linkers. It is injected at five points on each side of the face and spreads naturally beneath the skin, drawing in water and supporting the skin's own collagen and elastin. The result is plumper, better-hydrated skin with improved firmness. Its few injection points make sessions quick, and it is also widely used on the neck and hands.

Choose Rejuran Healer if…

Your skin is sensitive, red or recovering from irritation
Enlarged pores, fine lines or shallow scars are your main concern
You want to strengthen thin, fragile skin
You can fit three sessions into your plan, or continue later

Choose Profhilo if…

Your skin feels dry or tight and has started to look crepey
Mild laxity on the face or neck is your main concern
You prefer fewer injections per session
You want to treat the neck, hands or décolletage too

Can you combine them?

Yes, and many people do. Profhilo hydrates and firms while Rejuran repairs, so together they cover hydration, structure and skin health. Your doctor may alternate them a few weeks apart or use them in different areas in one session, such as Profhilo on the neck and Rejuran on the face. Rejuran also appears in our Glass Skin Package(from ₩359,000).

Cost comparison

At Dernia Clinic Myeongdong, Rejuran Healer starts from ₩259,000 for 2cc and Profhilo from ₩390,000 for 2ml. A typical Rejuran course of three sessions starts from ₩777,000 and a Profhilo course of two from ₩780,000, so a full course of either costs about the same. See current plans on the Rejuran Healer price page and the Profhilo price page. Prices are in Korean won (KRW), exclude 10% VAT, and are confirmed at your consultation.

How our doctors decide

Your doctor looks at how your skin behaves: whether it is reactive, thin or scarred, or mainly dry and losing firmness. Reactive, textured skin points to Rejuran. Dehydrated, crepey skin points to Profhilo. If you have both, a combined plan often works best. Age matters less than skin behavior: a 30-year-old with reactive skin may need Rejuran first, while a 45-year-old with dry, thinning skin may benefit more from Profhilo.

Neither is injected during pregnancy or breastfeeding, over active infection, or without review if you take blood thinners or have a bleeding disorder; tell your doctor about any fish allergy before Rejuran. See how Rejuran builds on the Rejuran Healer results page, read our skin boosters guide, browse more comparisons, or book a consultation and a licensed doctor will recommend the right booster plan.

Is Rejuran or Profhilo better for fine lines?

Both help. Rejuran improves fine lines by strengthening and thickening the skin, while Profhilo softens them through deep hydration and improved firmness. Your skin type decides which works better for you.

Which hurts less?

Profhilo involves only ten injection points, so most people find it quicker and easier. Rejuran uses many small injections and is known to sting, which is why numbing cream is used.

How many sessions do I need?

Rejuran is usually done as three sessions about three to four weeks apart, and Profhilo as two sessions about four weeks apart. Maintenance is typically every six months.

Can I have Rejuran and Profhilo together?

Yes. They are often combined, either in different areas on the same day or alternated a few weeks apart. Your doctor will plan the sequence.

Is there downtime?

Rejuran leaves small bumps that usually settle within one to three days. Profhilo bumps usually settle within about 24 hours. Both are easy to fit into a trip.

Treatments compared

Rejuran Healer — PN repair booster
Profhilo — HA bio-remodeler
Rejuran Eye — finer PN for the eye area

Price, results and reviews

Rejuran Healer price in Seoul — 2cc and course pricing
Profhilo price in Seoul — session and course pricing
Profhilo results — what changes after each session
Rejuran Healer review — our medical team's verdict

Concerns and FAQs

Dehydrated skin — boosters and facials
Redness and rosacea — calming options
Does Rejuran hurt? — pain and numbing explained

More comparisons

Skinvive vs Profhilo — two HA boosters
Rejuran Healer vs exosome therapy — two repair approaches

Dernia Clinic Myeongdong

Rejuran Healer vs Profhilo: Which Is Right for You?