The detailed answer

Polynucleotides are chains of nucleotides, the building blocks of DNA. In Rejuran Healer, they are derived from salmon DNA and purified for injection into the skin. Once injected, PN is thought to support the skin's natural repair processes, improving hydration, elasticity and texture over a series of sessions. That is why Rejuran is often nicknamed the "salmon injection" or "salmon DNA skin booster" in Korea and online. Because it supports repair rather than adding volume, results build gradually over several weeks.

What it is and what it is not

It is a purified, medical-grade injectable made from salmon-derived DNA fragments.
It is not salmon oil, fish collagen or a food product.
It is animal-derived, which matters if you avoid animal products for ethical, dietary or religious reasons.

Fish allergy and other safety points

Because PN is derived from fish, tell your doctor if you have a fish or salmon allergy, or any history of severe allergic reactions. The doctor will weigh the risk with you and may recommend a different booster. If you have reacted to any injectable before, bring details of the product and what happened. Skin boosters are also usually postponed during pregnancy or breastfeeding, with an active skin infection in the area, or if you have a bleeding disorder or take blood thinners. Your doctor confirms suitability before treatment.

Alternatives without PN

If Rejuran is not right for you, other skin boosters work in different ways: hyaluronic acid skin boosters for hydration, Profhilo for high-concentration HA hydration, and Juvelook for collagen stimulation. Compare them in Rejuran Healer vs Profhilo and our skin boosters guide.

What we recommend

Mention allergies and any dietary or religious preferences at your consultation so the doctor can choose the right product. If Rejuran suits you, plan three sessions for the best result; see when you will see Rejuran results. Rejuran Healer at Dernia starts from ₩259,000 for 2cc. Prices are in Korean won (KRW), exclude 10% VAT, and are confirmed at your consultation. See the Rejuran Healer price guide, browse all treatments, or book a consultation to choose the right booster for you.

Can I have Rejuran if I am allergic to fish?

Discuss it with your doctor first. Rejuran is highly purified, but because it is salmon-derived, the doctor may recommend a different booster if you have a fish allergy or a history of severe allergic reactions.

Is Rejuran vegan or vegetarian?

No. It is derived from salmon DNA, so it is an animal-derived product. Ask your doctor about the source of any alternative booster you are considering.

Is Rejuran Eye also made from salmon?

Yes. Rejuran Eye uses polynucleotide technology in a formulation for the delicate eye area.

Does Rejuran hurt?

Numbing cream is applied, but the many small injections can sting. See Rejuran pain and numbing.

Rejuran

Rejuran Healer — PN skin booster
Rejuran Eye — PN for the eye area
Rejuran Healer price — from ₩259,000 for 2cc
Rejuran Healer review — our medical team's verdict

Alternatives

Hyaluronic acid skin booster — hydration without PN
Profhilo — high-concentration HA
Rejuran Healer vs exosome therapy — two repair approaches

Guides and questions

Skin boosters explained — PN, PDLLA, HA and exosomes
When will I see Rejuran results? — timeline
Downtime after skin boosters — what to expect

Dernia Clinic Myeongdong

Is Rejuran made from salmon?